Section of Endocrinology, Metabolism and Diabetes, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA. Department of Pediatrics, University of Kentucky, Lexington, KY 40506, USA. Section of Endocrinology, Metabolism and Diabetes, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA; The Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.